LabFUS is an MR guided focused ultrasound device which enable precise heating of a targeted volume to a well controlled temperature.
New fields like molecular imaging [1,2], cellular therapy , local drug delivery [4-8] or temperature controlled localized gene expression in gene therapy [9-14], have highlighted the need for a way to increase in a controlled manner and non invasively the local temperature within an organ.
LabFUS is an efficient research tool to heat, completely non invasively, a target volume to a predefined temperature. It uses focused ultrasound to heat and MR temperature images to precisely control the energy deposition within the target to follow a predefined temperature profile.
Based on TargetedFUS technology, LabFUS is highly modular in order to correspond to the various needs of experimental research
LabFUS comes in several configurations adapted to different experimental needs:
||single element, custom size
||annular, linear or 2D phased array, custom size
||linear or 2D phased array, custom size
||2D phased array, custom size
Transducer positioning system
To ensure good performance at high field strength, the mechanical positioning system has been designed without any paramagnetic materials. The positioning system needs to be customized for the chosen transducer, the required degrees of freedom for the transducer motion and the available space in the magnet bore
The controlling software, based on Thermoguide, is very open by design so that researcher can plug in their own data processing tools in the image processing pipeline. The software can also be configured to perform sophisticated image processing by means of the included scripting architecture. In addition to the standard software, IGT also provides a sophisticated feedback control mechanism based on temperature images to precisely reach and maintain a predefined temperature over a volume of interest. This fine temperature control is essential for experiments in the fields of molecular imaging, local drug delivery, temperature controlled gene expression.
- Weissleder R, Mahmood U. "Molecular imaging." Radiology. 2001 May;219(2):316–33.
- Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N. "Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery." J Neurosurg. 2006 Sep;105(3):445–54.
- O. Hauger, C. Delalande, H. Trillaud, C. Deminiere, B. Quesson, H. Kahn, J. Cambar, C. Combe and N. Grenier. "MR imaging of intrarenal macrophage infiltration in an experimental model of nephrotic syndrome" Magn Reson Med, 1999;41:156–62
- Ng KY, Liu Y. "Therapeutic ultrasound: its application in drug delivery." Med Res Rev. 2002 Mar;22(2):204–23
- R. Salomir, J. Palussiere, S. L. Fossheim, A. Rogstad, U. N. Wiggen, N. Grenier and C. T. Moonen. "Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: a feasibility study in vivo" J Magn Reson Imaging, 2005;22:534–40
- C. Bos, M. Lepetit-Coiffe, B. Quesson and C. T. Moonen. "Simultaneous monitoring of temperature and T1: methods and preliminary results of application to drug delivery using thermosensitive liposomes" Magn Reson Med, 2005;54:1020–4
- Dromi S, Frenkel V, Luk A, Traughber B, Angstadt M, Bur M, Poff J, Xie J, Libutti SK, Li KC, Wood BJ. "Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect." Clin Cancer Res. 2007 May 1;13(9):2722–7
- O'Neill BE, Li KC. "Augmentation of targeted delivery with pulsed high intensity focused ultrasound" Int J Hyperthermia. 2008 May 31:1–15
- E. Guilhon, B. Quesson, F. Moraud-Gaudry, H. de Verneuil, P. Canioni, R. Salomir, P. Voisin and C. T. Moonen. "Image-guided control of transgene expression based on local hyperthermia" Mol Imaging, 2003;2:11–7
- E. Guilhon, P. Voisin, J. A. de Zwart, B. Quesson, R. Salomir, C. Maurange, V. Bouchaud, P. Smirnov, H. de Verneuil, A. Vekris, P. Canioni and C. T. Moonen. "Spatial and temporal control of transgene expression in vivo using a heat-sensitive promoter and MRI-guided focused ultrasound" J Gene Med, 2003;5:333–42
- Du X,Qiu B, Zhan X, Kolmakova A, Gao F, Hofmann LV, Cheng L, Chatterjee S, Yang X. "Radiofrequency-enhanced vascular gene transduction and expression for intravascular MR imaging-guided therapy: feasibility study in pigs."Radiology, 2005 Sept;236:939–44
- Frenkel V, Li KC. "Potential role of pulsed-high intensity focused ultrasound in gene therapy" Future Oncol. 2006 Feb;2(1):111–9
- Moonen CT. "Spatio-temporal control of gene expression and cancer treatment using magnetic resonance imaging-guided focused ultrasound." Clin Cancer Res. 2007 Jun 15;13(12):3482–9.
- Huang SL. "Liposomes in ultrasonic drug and gene delivery" Adv Drug Deliv Rev. 2008 Jun 30;60(10):1167–76